{"product_id":"hdacs-ezh2-in-1","title":"HDACs\/EZH2-IN-1","description":"\u003cp\u003e\u003cstrong\u003eHDACs\/EZH2-IN-1\u003c\/strong\u003e (Compound 22a) is a certified reference standard supplied by Quantimol for laboratory and scientific research.\u003c\/p\u003e\u003cp\u003eHDACs\/EZH2-IN-1 is a potent dual inhibitor of histone deacetylases (HDACs) and the histone methyltransferase EZH2. It inhibits EZH2 Y641N with a 98% inhibition rate at 50 nM, and selectively inhibits HDAC1 (IC50: 0.23 μM) and HDAC6 (IC50: 0.07 μM). This compound exerts antiproliferative effects on diffuse large B-cell lymphoma (DLBCL) cells harbouring EZH2 mutations and on various acute myeloid leukaemia (AML) cell lines, and induces cell differentiation and apoptosis.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eKey properties:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eTargets: HDAC1, HDAC6, EZH2 (dual epigenetic inhibitor)\u003c\/li\u003e\n\u003cli\u003eEZH2 Y641N inhibition: 98% at 50 nM\u003c\/li\u003e\n\u003cli\u003eHDAC1 IC50: 0.23 μM | HDAC6 IC50: 0.07 μM\u003c\/li\u003e\n\u003cli\u003ePurity: ≥98% (HPLC)\u003c\/li\u003e\n\u003cli\u003eStorage: -20°C, protected from light\u003c\/li\u003e\n\u003cli\u003eSolubility: DMSO (recommended)\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eApplications:\u003c\/strong\u003e Epigenetic cancer research, DLBCL and AML biology, HDAC\/EZH2 dual inhibition studies, apoptosis and differentiation assays, lymphoma drug discovery.\u003c\/p\u003e\u003cp\u003eSupplied by Quantimol as a certified reference standard for research use only. Not for human or veterinary use.\u003c\/p\u003e","brand":"Quantimol","offers":[{"title":"1 Each","offer_id":53322933797201,"sku":"QM-0154276","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1030\/0211\/2337\/files\/quantimol-021.png?v=1773515276","url":"https:\/\/quantimol.com\/products\/hdacs-ezh2-in-1","provider":"Quantimol","version":"1.0","type":"link"}