{"product_id":"p60-l3-vhl","title":"P60-L3-VHL","description":"\u003cp\u003e\u003cstrong\u003eP60-L3-VHL\u003c\/strong\u003e is a PROTAC (Proteolysis Targeting Chimera)-class Foxp3 degrader supplied by Quantimol as a certified reference standard for laboratory and scientific research.\u003c\/p\u003e\u003cp\u003eP60-L3-VHL reduces cell differentiation and Foxp3 expression in activated regulatory T (Treg) cells in vitro and has demonstrated anti-tumor activity in preclinical models.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCompound architecture:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eE3 ligase ligand (VHL binder): HY-162945\u003c\/li\u003e\n\u003cli\u003eTarget protein ligand (Foxp3 binder): HY-162946\u003c\/li\u003e\n\u003cli\u003eLinker: HY-162947\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eKey properties:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eCompound class: PROTAC \/ Targeted protein degrader\u003c\/li\u003e\n\u003cli\u003eTarget: Foxp3 (Forkhead box P3)\u003c\/li\u003e\n\u003cli\u003eE3 ligase: VHL (Von Hippel-Lindau)\u003c\/li\u003e\n\u003cli\u003eApplication: Treg biology, immuno-oncology, cancer immunotherapy research\u003c\/li\u003e\n\u003cli\u003eStorage: -20°C, protected from light and moisture\u003c\/li\u003e\n\u003cli\u003eSolubility: DMSO (recommended)\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eSupplied by Quantimol as a high-purity reference standard for research use only. Not for human or veterinary use.\u003c\/p\u003e","brand":"Quantimol","offers":[{"title":"1 mg","offer_id":53311315542353,"sku":"QM-0111495-01","price":545.72,"currency_code":"GBP","in_stock":true},{"title":"5 mg","offer_id":53311315575121,"sku":"QM-0111495-02","price":1289.3,"currency_code":"GBP","in_stock":true},{"title":"10 mg","offer_id":53311315607889,"sku":"QM-0111495-03","price":2032.88,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1030\/0211\/2337\/files\/quantimol-021.png?v=1773515276","url":"https:\/\/quantimol.com\/products\/p60-l3-vhl","provider":"Quantimol","version":"1.0","type":"link"}