1,2,3,4,7,8,9-Heptachlorodibenzofuran [CAS 55673-89-7]
1,2,3,4,7,8,9-Heptachlorodibenzofuran [CAS 55673-89-7]
SKU:QM-0052083-01
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Product Details
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Description
1,2,3,4,7,8,9-Heptachlorodibenzofuran (1,2,3,4,7,8,9-HpCDF) is a compound that induces the expression of CYP1A1 and CYP1B1 genes in human peripheral blood lymphocytes, while also promoting the expression of the aryl hydrocarbon receptor repressor (AhRR) . 1,2,3,4,7,8,9-Heptachlorodibenzofuran can increase ethoxyresorufin-O-deethylase (EROD) activity in isolated human peripheral blood lymphocytes in a concentration-dependent manner, which serves as a marker of CYP1A1 activity. Furthermore, 1,2,3,4,7,8,9-Heptachlorodibenzofuran exhibits immunosuppressive effects by reducing the number of splenic plaque-forming cells in mice and increasing aryl hydrocarbon hydroxylase (AHH) activity in liver microsomes of mice injected with sheep red blood cells. 1,2,3,4,7,8,9-Heptachlorodibenzofuran can be used in research in the fields of immunology, metabolic diseases, and environmental toxicology[1][2][3][4].
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CAS Number
[55673-89-7]
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Molecular Formula
C12HCl7O
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Molecular Weight
409.31
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Smiles
C1=C2C(=C(C(=C1Cl)Cl)Cl)C3=C(O2)C(=C(C(=C3Cl)Cl)Cl)Cl
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Target
Aryl Hydrocarbon Receptor; Cytochrome P450
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Shipping Conditions
Room temperature
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Hazard Statement
H300-H310-H330-H410
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Precautions
P260-P262-P264-P270-P271-P273-P280-P284-P302+P352-P304+P340-P330-P361+P364-P391-P403+P233-P405-P501
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1,2,3,4,7,8,9-Heptachlorodibenzofuran [CAS 55673-89-7]
1,2,3,4,7,8,9-Heptachlorodibenzofuran is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.