1,2,4-Trihydroxybenzene [CAS 533-73-3]
1,2,4-Trihydroxybenzene [CAS 533-73-3]
SKU:QM-0179858-01
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Product Details
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Description
1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) is an ER stress inducer that targets proteins such as PKR-like ER kinase PERK to induce cytotoxicity. 1,2,4-Trihydroxybenzene selectively activates eIF2α phosphorylation, activates the PERK-eIF2α signaling pathway and induces stress granule formation. 1,2,4-Trihydroxybenzene subsequently exacerbates oxidative stress and causes DNA double-strand breaks, destroying organelles such as mitochondria and ER, and inducing cell death. 1,2,4-Trihydroxybenzene also has the potential to exhibit anti-tumor effect, increase blood pressure, and relieve spasm[1][2][3][4].
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CAS Number
[533-73-3]
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Molecular Formula
C6H6O3
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Molecular Weight
126.11
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Smiles
OC1=CC=C(O)C=C1O
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Target
Apoptosis; Eukaryotic Initiation Factor (eIF) ; PERK; Potassium Channel
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Isoform
EIF2
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Purity
99.32
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Solubility
DMSO : 50 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H318, H335
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Precautions
H302, H315, H318, H335
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1,2,4-Trihydroxybenzene [CAS 533-73-3]
1,2,4-Trihydroxybenzene is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.