1,4-Naphthoquinone [CAS 130-15-4]

1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM) . 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models[1][2][3][4][5].

[130-15-4]

C10H6O2

158.16

O=C1C=CC(C2=C1C=CC=C2)=O

Bacterial; DNA/RNA Synthesis; Monoamine Oxidase; NF-κB; TNF Receptor

DNA Polymerases; MAO-A; MAO-B

99.97

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H301+H311, H314, H317, H330, H335, H410

H301+H311, H314, H317, H330, H335, H410