1"-α-Azido-RDPr

1"-α-Azido-RDPr (Compound 11) is an analog of adenosine diphosphate ribose, and exhibits inhibitory efficacy against the SARS-CoV-2 nonstructural protein macodomain SARS-CoV-2 NSP3 Mac1 with an IC50 of 30 nM[1].

C16H26N10O13P2

628.38

O[C@@H]1[C@H](O)[C@@H](OP(OP(O)(OC[C@H]2O[C@H](N=[N+]=[N-])[C@H](O)[C@@H]2O)=O)(O)=O)O[C@@]1(C#N)C3=CC=C4N3N=CN=C4N.N.N

SARS-CoV

Room temperature