1-Dehydro-[10]-gingerdione [CAS 136826-50-1]

1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS -induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research[1].

[136826-50-1]

C21H30O4

346.46

O=C(CC(CCCCCCCCC)=O)/C=C/C1=CC=C(C(OC)=C1)O

IKK; NF-κB

10 mM in DMSO

Room temperature