1-Ethynylpyrene is an aryl acetylenic inhibitor of cytochromes P450 1A1, 1A2, and 2B1 with IC50s of 0.18, 0.32, and 0.04 μM, respectively[1]. 1-Ethynylpyrene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[34993-56-1]
Molecular Formula
C18H10
Molecular Weight
226.28
Smiles
C#CC1=C(C2=C34)C=CC4=CC=CC3=CC=C2C=C1
Target
Cytochrome P450
Purity
99.53
Solubility
DMSO : 9.09 mg/mL (ultrasonic; warming; heat to 60°C)