1 (R),2 (S) -epoxy Cannabidiol (Compound 2a) is a structural analogue of phytocannabinoidsphytocannabinoids. 1 (R),2 (S) -epoxy Cannabidiol exhibits potent inhibitory activity against Wnt/β-catenin pathway. 1 (R),2 (S) -epoxy Cannabidiol is promising for research of neuroprotective agents[1].