12-Hydroxynevirapine [CAS 133627-24-4]
12-Hydroxynevirapine [CAS 133627-24-4]
SKU:QM-0149789-01
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Product Details
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Description
12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine. Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine[1][2].
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CAS Number
[133627-24-4]
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Molecular Formula
C15H14N4O2
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Molecular Weight
282.3
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Smiles
O=C1NC2=C(CO)C=CN=C2N(C3CC3)C4=NC=CC=C14
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Target
Drug Metabolite
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Purity
96.04
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Solubility
10 mM in DMSO
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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12-Hydroxynevirapine [CAS 133627-24-4]
12-Hydroxynevirapine is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.