155H1

155H1 (Compound 11) is a stapled peptide, that covalently binds hMcl1 (172-323) with IC50 of 18 nM[1].

C79H120FN19O23S

1754.98

NC(NCCC[C@H](NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@@H](NC([C@H](CNC(C1=C(OC)C=CC(S(=O)(F)=O)=C1)=O)NC(C)=O)=O)[C@H](CC)C)=O)=O)=O)=O)=O)C(N[C@]2(CCC/C=C\CCC[C@@](C)(C(N[C@@H](CC3=CC=CC=C3)C(N)=O)=O)NC([C@H](CC(O)=O)NC(CNC([C@H]([C@@H](C)CC)NC2=O)=O)=O)=O)C)=O)=N

Bcl-2 Family

10 mM in DMSO

Room temperature