18-Hydroxy-11-deoxy corticosterone [CAS 379-68-0]
18-Hydroxy-11-deoxy corticosterone [CAS 379-68-0]
SKU:QM-0053493
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Product Details
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Description
18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields[1].
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CAS Number
[379-68-0]
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Molecular Formula
C21H30O4
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Molecular Weight
346.46
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Smiles
OC[C@@]12[C@](CC[C@@H]2C(CO)=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1
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Target
Angiotensin Receptor; Drug Metabolite; Melanocortin Receptor; Mineralocorticoid Receptor
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Shipping Conditions
Room temperature
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18-Hydroxy-11-deoxy corticosterone [CAS 379-68-0]
18-Hydroxy-11-deoxy corticosterone is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.