1A-116 [CAS 1430208-73-3]

1A-116, a potent Rac1 inhibitor, is specific for W56 residues, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo[1][2][3].

[1430208-73-3]

C16H16F3N3

307.31

N=C(NC1=CC=CC=C1C(F)(F)F)NC2=CC(C)=CC(C)=C2

Apoptosis; Ras

99.72

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H315, H319, H335

H315, H319, H335