(1R,5S) -Thalidomide-3,8-diazabicyclo[3.2.1]octane- (1R,4r) -cyclohexane-NH-Boc
(1R,5S) -Thalidomide-3,8-diazabicyclo[3.2.1]octane- (1R,4r) -cyclohexane-NH-Boc
SKU:QM-0084353
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![(1R,5S) -Thalidomide-3,8-diazabicyclo[3.2.1]octane- (1R,4r) -cyclohexane-NH-Boc](http://quantimol.com/cdn/shop/files/quantimol-021.png?v=1773515276&width=1445)
Product Details
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Description
(1R,5S) -Thalidomide-3,8-diazabicyclo[3.2.1]octane- (1R,4r) -cyclohexane-NH-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide and the corresponding Linker. (1R,5S) -Thalidomide-3,8-diazabicyclo[3.2.1]octane- (1R,4r) -cyclohexane-NH-Boc can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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Molecular Formula
C31H41N5O6
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Molecular Weight
579.69
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Smiles
O=C1NC(CCC1N2C(C3=C(C=CC(N4C[C@H]5N([C@H](CC5)C4)C[C@H]6CC[C@@H](CC6)NC(OC(C)(C)C)=O)=C3)C2=O)=O)=O
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Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
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Isoform
Cereblon
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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(1R,5S) -Thalidomide-3,8-diazabicyclo[3.2.1]octane- (1R,4r) -cyclohexane-NH-Boc
(1R,5S) -Thalidomide-3,8-diazabicyclo[3.2.1]octane- (1R,4r) -cyclohexane-NH-Boc is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.