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(1R) -IDH889 [CAS 1429179-08-7]

(1R) -IDH889 [CAS 1429179-08-7]

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QM-0137442-01

£412.07 GBP
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Product Details

  • Description

    (1R) -IDH889 is the isomer of IDH889 , and can be used as an experimental control. IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1].

  • CAS Number

    [1429179-08-7]

  • Molecular Formula

    C23H25FN6O2

  • Molecular Weight

    436.48

  • Smiles

    O=C1OC[C@H](C(C)C)N1C2=NC(N[C@@H](C3=NC=C(C4=CC=C(F)C(C)=C4)C=N3)C)=NC=C2

  • Target

    Isocitrate Dehydrogenase (IDH)

  • Purity

    98.83

  • Solubility

    DMSO : 200 mg/mL (ultrasonic)

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H302-H315-H319-H335

  • Precautions

    P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Variant Variant total Quantity Price Variant total
10 mM - 1 mLQM-0137442-01
10 mM - 1 mLQM-0137442-01
£268.20
£412.07/ea
 £0.00
£268.20
£412.07/ea
 £0.00
5 mgQM-0137442-02
5 mgQM-0137442-02
£279.00
£426.65/ea
 £0.00
£279.00
£426.65/ea
 £0.00
10 mgQM-0137442-03
10 mgQM-0137442-03
£465.30
£678.15/ea
 £0.00
£465.30
£678.15/ea
 £0.00
25 mgQM-0137442-04
25 mgQM-0137442-04
£790.20
£1,116.77/ea
 £0.00
£790.20
£1,116.77/ea
 £0.00
50 mgQM-0137442-05
50 mgQM-0137442-05
£1,116.00
£1,556.60/ea
 £0.00
£1,116.00
£1,556.60/ea
 £0.00
100 mgQM-0137442-06
100 mgQM-0137442-06
£1,674.00
£2,309.90/ea
 £0.00
£1,674.00
£2,309.90/ea
 £0.00
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(1R) -IDH889 [CAS 1429179-08-7]

(1R) -IDH889 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.