2′-Deoxy-2′-fluoroadenosine [CAS 64183-27-3]
2′-Deoxy-2′-fluoroadenosine [CAS 64183-27-3]
SKU:QM-0178772-01
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Product Details
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Description
2′-Deoxy-2′-fluoroadenosine is a fluorinated deoxyadenosine with antitumor and antiviral activity, able to interfere with viral or cancer cell replication by being incorporated into DNA. 2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde) . 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP[1][2][3].
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CAS Number
[64183-27-3]
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Molecular Formula
C10H12FN5O3
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Molecular Weight
269.24
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Smiles
OC[C@@H]1[C@@H](O)[C@@H](F)[C@H](N2C(N=CN=C3N)=C3N=C2)O1
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Target
Nucleoside Antimetabolite/Analog
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Purity
99.71
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Solubility
DMSO : 50 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, stored under nitrogen)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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2′-Deoxy-2′-fluoroadenosine [CAS 64183-27-3]
2′-Deoxy-2′-fluoroadenosine is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.