2'-O-Me-5-I-U-3'-phosphoramidite

2’-O-Me-5-I-U-3’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

C40H48IN4O9P

886.71

COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OC)[C@H](N5C(NC(C(I)=C5)=O)=O)O4

Nucleoside Antimetabolite/Analog

10 mM in DMSO

Room temperature