20 (S) -Hydroxycholesterol [CAS 516-72-3]
20 (S) -Hydroxycholesterol [CAS 516-72-3]
SKU:QM-0140791-01
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Product Details
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Description
20 (S) -Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC50 of ~30 μM (Hedgehog). 20 (S) -Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20 (S) -Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin to promote bone regeneration. 20 (S) -Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis[1][2][3].
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CAS Number
[516-72-3]
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Molecular Formula
C27H46O2
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Molecular Weight
402.65
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Smiles
C[C@@]1([C@@]2([H])[C@@](C)(O)CCCC(C)C)[C@](CC2)([H])[C@@](CC=C3[C@@]4(CC[C@H](O)C3)C)([H])[C@]4([H])CC1
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Target
Endogenous Metabolite; Smo
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Isoform
Human Endogenous Metabolite
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Purity
99.29
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Solubility
DMSO : 12.5 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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20 (S) -Hydroxycholesterol [CAS 516-72-3]
20 (S) -Hydroxycholesterol is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.