22- (4′-py) -JA [CAS 1178895-15-2]

22- (4′-py) -JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.) . 22- (4′-py) -JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22- (4′-py) -JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) . 22- (4′-py) -JA has potent anticancer activity against non-small cell lung cancer (NSCLC) [1].

[1178895-15-2]

C32H30N4O8

598.6

O=C(C1=C(C2=O)C[C@@]3([H])[C@H](C#N)N4[C@@H](COC(C5=CC=NC=C5)=O)C(C(C(OC)=C(C)C6=O)=O)=C6C[C@@]4([H])[C@@]([H])1N3C)C(OC)=C2C

Akt; mTOR

10 mM in DMSO

Room temperature