2BAct [CAS 2143542-28-1]

2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer.

[2143542-28-1]

C19H16ClF3N4O3

440.8

O=C(C(C=N1)=NC=C1C(F)F)NC(C2)(C3)CC23NC(COC(C=C4)=CC(F)=C4Cl)=O

Eukaryotic Initiation Factor (eIF)

EIF2

99.77

DMSO : 100 mg/mL (ultrasonic)

4°C (Powder, protect from light)

Room Temperature