(2S,3R) -LP99 [CAS 1808948-28-8]

(2S,3R) -LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R) -LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R) -LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1].

[1808948-28-8]

C26H30ClN3O4S

516.05

CC(CS(=O)(N[C@@H]([C@@H](N1C2=CC3=C(C(C)=CC(N3C)=O)C=C2)C4=CC=C(C=C4)Cl)CCC1=O)=O)C

Epigenetic Reader Domain

BRD7; BRD9

99.4

10 mM in DMSO

-20°C, 3 years (Powder)

Blue Ice