(2S,3S,11bR) -Dihydrotetrabenazine [CAS 862377-27-3]

(2S,3S,11bR) -Dihydrotetrabenazine ((2S,3S,11bR) -DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. (2S,3S,11bR) -Dihydrotetrabenazine inhibits vesicular transport of monoamine neurotransmitters like dopamine and serotonin, reducing their synaptic release. (2S,3S,11bR) -Dihydrotetrabenazine is promising for research of Huntington's chorea and other hyperkinetic disorders[1].

[862377-27-3]

C19H29NO3

319.44

COC1=C(OC)C=C2CCN(C[C@@H]([C@H](C3)O)CC(C)C)[C@@]3([H])C2=C1

Monoamine Transporter

Room temperature