3′,4′,7-Trihydroxyflavone [CAS 2150-11-0]
3′,4′,7-Trihydroxyflavone [CAS 2150-11-0]
SKU:QM-0165115-01
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Product Details
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Description
3′,4′,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC50 = 1.89 μM) and COX-1 (IC50 = 36.37 μM). 3′,4′,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-α. 3′,4′,7-Trihydroxyflavone inhibits H2O2-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3′,4′,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3′,4′,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3′,4′,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine -induced memory deficits in mice[1][2][3][4][5][6][7][8][9].
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CAS Number
[2150-11-0]
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Molecular Formula
C15H10O5
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Molecular Weight
270.24
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Smiles
O=C1C2=CC=C(O)C=C2OC(C3=CC(O)=C(O)C=C3)=C1
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Target
Akt; Apoptosis; Bacterial; Bcl-2 Family; Beta-lactamase; Caspase; COX; ERK; Interleukin Related; JNK; Lactate Dehydrogenase; NO Synthase; Nuclear Factor of activated T Cells (NFAT) ; p38 MAPK; Reactive Oxygen Species (ROS) ; SOD; STAT
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Purity
98
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Solubility
DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
RT, protect from light
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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3′,4′,7-Trihydroxyflavone [CAS 2150-11-0]
3′,4′,7-Trihydroxyflavone is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.