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3-Hydroxy Midostaurin [CAS 179237-49-1]
3-Hydroxy Midostaurin [CAS 179237-49-1]
SKU:QM-0057926
£702.46 GBP
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Product Details
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Description
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
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CAS Number
[179237-49-1]
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Molecular Formula
C35H30N4O5
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Molecular Weight
586.64
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Smiles
OC1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(O[C@@H](N7C5=C2C8=C7C=CC=C8)C[C@H]([C@H]6OC)N(C(C9=CC=CC=C9)=O)C)C)=O
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Target
FLT3
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Purity
97.02
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Solubility
10 mM in DMSO
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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3-Hydroxy Midostaurin [CAS 179237-49-1]
3-Hydroxy Midostaurin is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.