3-Hydroxyflunitrazepam [CAS 67739-71-3]
3-Hydroxyflunitrazepam [CAS 67739-71-3]
SKU:QM-0106851-01
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Product Details
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Description
3-Hydroxyflunitrazepam (3-OH FNTZ) is the major metabolite of Flunitrazepam (FNTZ), generated via 3-hydroxylation by CYP3A4 (Km = 286 μM), and represents the dominant metabolic pathway (>80%) in liver microsomes. Its formation is significantly inhibited by CYP3A4 inhibitors such as Ketoconazole (IC50 = 0.11 μM) and Ritonavir (HY-90001) (IC50 = 0.041 μM), indicating a strong dependence on CYP3A4 activity and potential drug interactions[1].
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CAS Number
[67739-71-3]
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Molecular Formula
C16H12FN3O4
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Molecular Weight
329.28
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Smiles
O=C1C(O)N=C(C2=CC=CC=C2F)C3=CC([N+]([O-])=O)=CC=C3N1C
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Target
Cytochrome P450; Drug Metabolite
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Shipping Conditions
Room temperature
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3-Hydroxyflunitrazepam [CAS 67739-71-3]
3-Hydroxyflunitrazepam is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.