3’-O-Me-G (iBu) -2’-phosphoramidite [CAS 179479-04-0]

3’-O-Me-G (iBu) -2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) [1].

[179479-04-0]

C45H56N7O9P

869.94

O=C1C2=C(N([C@H]3[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@H](OC)[C@@H](COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6)O3)C=N2)NC(NC(C(C)C)=O)=N1

Nucleoside Antimetabolite/Analog

95

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature