3-Oxo-cinobufagin [CAS 6869-66-5]
3-Oxo-cinobufagin [CAS 6869-66-5]
SKU:QM-0125666
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Product Details
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Description
3-Oxo-cinobufagin (compound 8) is a potential anticancer compound that can be isolated from the broth of M. spinosus by high-performance liquid chromatography. Compared to other isolated compounds, the hydroxyl group at the C-5 position of 3-Oxo-cinobufagin is further oxidized or isomerized, significantly reducing its cytotoxic activity against most cell lines (except HEL), while increasing its activity against the BEL cell line. The IC50 values of 3-Oxo-cinobufagin's cytotoxicity against cancer cells are: 71.3 μM (HepG2), 90.2 μM (SMMC-7221), 0.11 μM (BEL-7402), 72.5 μM (K562), 5.3 μM (HL-60), and 12 nM (HEL) [1].
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CAS Number
[6869-66-5]
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Molecular Formula
C26H32O6
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Molecular Weight
440.53
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Smiles
C[C@]12[C@@]3([C@@]4([H])[C@]([C@@]5([C@](CC(CC5)=O)([H])CC4)C)([H])CC2)[C@]([C@@H]([C@@H]1C(C=C6)=COC6=O)OC(C)=O)([H])O3
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Target
Others
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Shipping Conditions
Room temperature
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3-Oxo-cinobufagin [CAS 6869-66-5]
3-Oxo-cinobufagin is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.