3-Oxobetulin acetate [CAS 136587-07-0]
3-Oxobetulin acetate [CAS 136587-07-0]
SKU:QM-0088224
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Product Details
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Description
3-Oxobetulin acetate (28-O-Acetyl-3-Oxobetulin; 3-oxo-28-O-Acetylbetulin) is a derivative of betulin , a cholesterol biosynthesis inhibitor. 3-Oxobetulin acetate inhibits the growth of P388 murine lymphocytic leukemia cells (EC50=0.12 μg/mL) and human MCF-7 breast cancer, SF-268 CNS cancer, H460 lung cancer, and KM20L2 colon cancer cells (GI50s=8, 10.6, 5.2, and 12.7 μg/mL), but not BxPC-3 pancreatic cancer cells or DU145 prostate cancer cells (GI50s=>10 μg/mL for both). 3-Oxobetulin acetate inhibits the replication of X4-tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblastoid cells (IC50=13.4 μM). 3-Oxobetulin acetate is also effective against Listeria donovani amastigotes.
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CAS Number
[136587-07-0]
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Molecular Formula
C32H50O3
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Molecular Weight
482.74
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Smiles
CC1(C)C(CC[C@]2(C)[C@@]3([H])CC[C@]4([H])[C@@]5([H])[C@H](C(C)=C)CC[C@@](COC(C)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O
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Target
Bacterial; Drug Derivative; HIV
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Shipping Conditions
Room temperature
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3-Oxobetulin acetate [CAS 136587-07-0]
3-Oxobetulin acetate is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.