(32-Carbonyl) -RMC-5552 [CAS 2382768-55-8]

(32-Carbonyl) -RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl) -RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K- (T389), p-4E-BP1- (T37/36), AND p-AKT1/2/3- (S473) ) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2) [1].

[2382768-55-8]

C93H134N10O24

1776.11

NC1=C2C(C3=CC=C(OC(N)=N4)C4=C3)=NN(C2=NC=N1)CC5=CC=C(CN(CC6)C(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(O[C@H]7[C@@H](C[C@@H](CC7)C[C@H]([C@@]8([H])OC([C@@]9([H])N(CCCC9)C(C([C@@]%10(O[C@](CC[C@H]%10C)([H])C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@H](C([C@@H]([C@@H](/C(C)=C/[C@H](C(C8)=O)C)O)OC)=O)C)C)OC)O)=O)=O)=O)C)OC)=O)=O)C6=C5

MTOR

95.41

DMSO : 146.67 mg/mL (ultrasonic)

4°C (Powder, sealed storage, away from moisture)

Room Temperature