(3S,5S,6R) -Navtemadlin [CAS 2459946-14-4]

(3S,5S,6R) -Navtemadlin is the isomer of Navtemadlin , and can be used as an experimental control. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].

[2459946-14-4]

C28H35Cl2NO5S

568.55

CC(C)S(C[C@@H](N1[C@@H](C2=CC=C(C=C2)Cl)[C@H](C3=CC(Cl)=CC=C3)C[C@](C)(C1=O)CC(O)=O)C(C)C)(=O)=O

MDM-2/p53

99.6

DMSO : ≥ 100 mg/mL

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335