1
/
of
1
α4β1 antagonist-1
α4β1 antagonist-1
SKU:QM-0013014
Price on request
Quantity
Request quote or documents
Product Details
-
Description
α4β1 antagonist-1 (Compound 4) is a highly selective α4β1 integrin antagonist (IC50=15 nM) . α4β1 antagonist-1 inhibits integrin-mediated cell adhesion and ERK1/2 signaling activation. α4β1 antagonist-1 also exhibits partial agonism toward αMβ2 integrin (EC50=23 nM) . α4β1 antagonist-1 is promising for research of chronic inflammatory diseases (e.g., rheumatoid arthritis, multiple sclerosis) and cancers[1].
-
Molecular Formula
C15H17F3N2O5
-
Molecular Weight
362.3
-
Smiles
[NH3+]C1=CC=C(C=C1)CC(N2CCC[C@H]2C(O)=O)=O.O=C([O-])C(F)(F)F
-
Target
ERK; Integrin
-
Isoform
ERK1; ERK2; α4β1
-
Shipping Conditions
Room temperature
Related Products
- QM-0012730-01 YTHDF2 ligand-1 [CAS 3093182-34-1]
- QM-0009574 α5-GABAA receptor modulator 1
- QM-0009265 α-syn aggregation inhibitor-1
- QM-0008903 β-Catenin modulator-8 [CAS 902586-39-4]
- QM-0002305 β-Secretase Inhibitor IV (Standard) [CAS 797035-11-1]
- QM-0142451-01 γ-Secretase modulator 4 [CAS 1420200-82-3]
- QM-0112884-01 σ1 Receptor antagonist-1 [CAS 1204401-49-9]
- QM-0149648-01 α7 Nicotinic receptor agonist-1 [CAS 220100-05-0]
- QM-0150540-01 β-FXR antagonist 1 [CAS 2295804-92-9]
- QM-0153508-01 α-Synuclein inhibitor 11
Other industry favorites
- QM-0012730-01 YTHDF2 ligand-1 [CAS 3093182-34-1]
- QM-0009574 α5-GABAA receptor modulator 1
- QM-0153235 α2AR agonist 1
- QM-0133147 α-Synuclein modulator 1 [CAS 3058709-40-0]
- QM-0015918 β2AR agonist 5 [CAS 2759727-47-2]
- QM-0015098 α2AR agonist 2 [CAS 719277-27-7]
α4β1 antagonist-1
α4β1 antagonist-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.