4-DAMP [CAS 1952-15-4]
4-DAMP [CAS 1952-15-4]
SKU:QM-0079836-01
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Product Details
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Description
4-DAMP (4-DAMP methiodide) is a potent and selective antagonist of M3 receptors and also has a high affinity for the closely-related M5 receptors. 4-DAMP combined with 5-Fluorouracil (5-Fu) could significantly reduce the cell viability and enhance apoptosis in MKN45 and BGC823 gastric cancer cells. 4-DAMP inhibits lipopolysaccharide (LPS) - and tobacco-induced pulmonary inflammation and reduces mucin 5AC (MUC5AC), oligomeric mucus/gel-forming secretion[1][2][3].
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CAS Number
[1952-15-4]
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Molecular Formula
C21H26INO2
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Molecular Weight
451.34
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Smiles
C[N+]1(C)CCC(OC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC1.[I-]
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Target
Apoptosis; EGFR; Interleukin Related; mAChR; MMP
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Isoform
MAChR3; mAChR5
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Concentration
10mM
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Purity
99.96
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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4-DAMP [CAS 1952-15-4]
4-DAMP is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.