4-FPBUA [CAS 2089636-93-9]

4-FPBUA is a semisynthetic analog of usnic acid that can enhance cellular blood-brain barrier (BBB) function and increase the transport of Amyloid β (Aβ) across monolayer cells. 4-FPBUA is also an inhibitor of mTOR, capable of enhancing cellular Autophagy, thereby reversing BBB disruption in vivo and being utilized in research for Alzheimer's disease[1].

[2089636-93-9]

C31H23FO7

526.51

C[C@]12C3=C(O)C(C)=C(O)C(C(/C=C/C4=CC=C(C5=CC=C(C=C5)F)C=C4)=O)=C3OC1=CC(O)=C(C2=O)C(C)=O

Autophagy; mTOR

Room temperature