4-Methoxylonchocarpin [CAS 51589-67-4]

4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS) -induced colitis mouse model[1].

[51589-67-4]

C21H20O4

336.38

OC1=C2C(OC(C)(C=C2)C)=CC=C1C(/C=C/C3=CC=C(C=C3)OC)=O

Interleukin Related; NF-κB; Toll-like Receptor (TLR)

98

10 mM in DMSO

-20°C, 3 years (Powder)

Blue Ice