5,6-Dihydro-5-Fluorouracil-13C,15N2 [CAS 1189492-99-6]
5,6-Dihydro-5-Fluorouracil-13C,15N2 [CAS 1189492-99-6]
SKU:QM-0006042-01
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Product Details
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Description
5,6-Dihydro-5-Fluorouracil-13C,15N2 (5-DHFU-13C,15N2) is the 13C- and 15N-labeled labeled 5,6-Dihydro-5-Fluorouracil. 5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50=13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model.
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CAS Number
[1189492-99-6]
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Molecular Formula
C3 13CH5F 15N2O2
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Molecular Weight
135.07
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Smiles
O=C1C(C[15NH][13C]([15NH]1)=O)F
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Target
Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog
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Shipping Conditions
Room temperature
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5,6-Dihydro-5-Fluorouracil-13C,15N2 [CAS 1189492-99-6]
5,6-Dihydro-5-Fluorouracil-13C,15N2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.