5-Hydroxymethylcytosine [CAS 1123-95-1]
5-Hydroxymethylcytosine [CAS 1123-95-1]
SKU:QM-0198717-01
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Product Details
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Description
5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET) 1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) [1][2].
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CAS Number
[1123-95-1]
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Molecular Formula
C5H7N3O2
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Molecular Weight
141.13
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Smiles
O=C1N=CC(CO)=C(N1)N
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Target
Endogenous Metabolite
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Purity
99.91
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Solubility
DMSO : 6.25 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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5-Hydroxymethylcytosine [CAS 1123-95-1]
5-Hydroxymethylcytosine is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.