5-Hydroxymethylcytosine-13C, d2
5-Hydroxymethylcytosine-13C, d2
SKU:QM-0089486
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Product Details
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Description
5-Hydroxymethylcytosine-13C, d2 is the 13C and deuterium labeled 5-Hydroxymethylcytosine. 5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET) 1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes)[2][3][4].
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Molecular Formula
C4 13CH5D2N3O2
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Molecular Weight
144.13
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Smiles
O=C1N=CC([13C]([2H])([2H])O)=C(N)N1
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Target
Isotope-Labeled Compounds
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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5-Hydroxymethylcytosine-13C, d2
5-Hydroxymethylcytosine-13C, d2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.