5-LOX-IN-8

5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory activity. 5-LOX-IN-8 suppresses IL-6, IL-1β, TNF-α and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. 5-LOX-IN-8 reduces disease activity in a DSS colitis model. 5-LOX-IN-8 can be used for research of inflammatory bowel disease (IBD) [1].

C29H34O6

478.58

COC1=C(OC)C(OC)=CC(CC2(CC3=CC(OC)=C(OC)C(OC)=C3)CC4=C(C=CC=C4)C2)=C1

IFNAR; Interleukin Related; Lipoxygenase; TNF Receptor

5-LOX; IL-1; IL-6; IL-8

Room temperature