7α,25-Dihydroxycholesterol [CAS 64907-22-8]
7α,25-Dihydroxycholesterol [CAS 64907-22-8]
SKU:QM-0138250-01
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Product Details
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Description
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183) . 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM) . 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2].
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CAS Number
[64907-22-8]
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Molecular Formula
C27H46O3
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Molecular Weight
418.65
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Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])[C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=C[C@H]3O)C)([H])CC1
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Target
EBI2/GPR183; Endogenous Metabolite
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Isoform
Human Endogenous Metabolite
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Purity
99.88
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Solubility
DMSO : 4.55 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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7α,25-Dihydroxycholesterol [CAS 64907-22-8]
7α,25-Dihydroxycholesterol is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.