7,4'-Dimethoxy-3-hydroxyflavone [CAS 13198-99-7]
7,4'-Dimethoxy-3-hydroxyflavone [CAS 13198-99-7]
SKU:QM-0012419
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Product Details
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Description
7,4'-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. 7,4'-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation with an IC50 of 1.4 μM. 7,4'-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation and PAR4 signaling pathways, including NF-κB, Ca2+/protein kinase C, Akt, ERK and p38. 7,4'-Dimethoxy-3-hydroxyflavone prevents vascular PAR4 expression, endothelial dysfunction and ameliorates oxidative stress in Streptozotocin (STZ) -induced diabetic mice. 7,4'-Dimethoxy-3-hydroxyflavone prevents thrombosis in mice without affecting bleeding time[1][2].
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CAS Number
[13198-99-7]
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Molecular Formula
C17H14O5
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Molecular Weight
298.29
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Smiles
COC1=CC=C(C=C1)C2=C(C(C3=CC=C(C=C3O2)OC)=O)O
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Target
Akt; Calcium Channel; ERK; NF-κB; p38 MAPK; PKC; Protease Activated Receptor (PAR) ; Reactive Oxygen Species (ROS)
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Isoform
PAR4
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Shipping Conditions
Room temperature
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7,4'-Dimethoxy-3-hydroxyflavone [CAS 13198-99-7]
7,4'-Dimethoxy-3-hydroxyflavone is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.