7,8-Didehydrocimigenol [CAS 150972-72-8]

7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis[1].

[150972-72-8]

C30H46O5

486.68

C[C@]12C3=CC[C@](C(C)([C@H](CC4)O)C)([H])[C@]54[C@@]3(CC[C@@]1([C@]6([H])[C@@]7(O[C@@H]([C@H](O7)C(C)(O)C)C[C@H]6C)[C@@H]2O)C)C5

NF-κB; PPAR

10 mM in DMSO

Room temperature