7-Hydroxystaurosporine [CAS 112953-11-4]
7-Hydroxystaurosporine [CAS 112953-11-4]
SKU:QM-0132650-01
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Product Details
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Description
7-Hydroxystaurosporine (UCN-01) is a synthetic derivative of Staurosporine with antitumor activity. 7-hydroxystaurosporine inhibits serine/threonine kinase AKT and calcium-dependent protein kinase C activity. 7-hydroxystaurosporine also activates indirectly cyclin-dependent kinases (CDKs). 7-hydroxystaurosporine arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis[1][2].
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CAS Number
[112953-11-4]
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Molecular Formula
C28H26N4O4
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Molecular Weight
482.53
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Smiles
C[C@]12N3C4=C(C5=CC=CC=C53)C([C@H](NC6=O)O)=C6C7=C4N([C@](C[C@H]([C@H]2OC)NC)([H])O1)C8=CC=CC=C78
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Target
Akt; Apoptosis; CDK; PKC
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Purity
97.5
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Solubility
DMSO : 28 mg/mL (ultrasonic; warming)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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7-Hydroxystaurosporine [CAS 112953-11-4]
7-Hydroxystaurosporine is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.