8α- (2-Methylacryloyloxy) -hirsutinolide-13-O-acetate [CAS 67667-71-4]

8α- (2-Methylacryloyloxy) -hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α- (2-Methylacryloyloxy) -hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively[1].

[67667-71-4]

C21H26O8

406.43

CC(OCC1=C([C@H](C[C@H]2C)OC(C(C)=C)=O)/C(OC1=O)=C\[C@](O[C@]23O)(CC3)C)=O

Cytochrome P450; Monoamine Oxidase

10 mM in DMSO

Room temperature