8-Deoxylactucin [CAS 65725-10-2]

8-Deoxylactucin is an orally active sesquiterpene lactone. 8-Deoxylactucin inhibits LPS -induced NO production in RAW264.7 macrophages with an IC50 value of 4.35 μM. 8-Deoxylactucin exerts anti-inflammatory effects by blocking the NF-κB pathway. 8-Deoxylactucin demonstrates hepatoprotective efficacy in LPS/D-galactosamine-induced acute hepatitis model of mice. 8-Deoxylactucin can be used for the study of inflammatory diseases and inflammatory liver injuries[1].

[65725-10-2]

C15H16O4

260.29

OCC([C@]1([H])[C@]2([H])[C@](CCC(C)=C13)([H])C(C(O2)=O)=C)=CC3=O

NF-κB; NO Synthase; Reactive Oxygen Species (ROS)

Room temperature