A-259745 [CAS 256934-83-5]

A-259745 is an orally active antimitotic agent that binds to the colchicine-binding site of tubulin. A-259745 exhibits potent in vitro cytotoxic activity against both multi-drug-resistant and non-multi-drug-resistant cancer cell lines, with ED50 values of 0.018 μM against HCT-15 and 0.028 μM against NCI-H460 cell lines. A-259745 inhibits tubulin polymerization, disrupts the dynamic equilibrium of the mitotic spindle, arrests dividing cells in metaphase, and subsequently induces apoptosis. A-259745 shows dose-dependent antitumor efficacy in murine tumor models. A-259745 can be used for the study of cancer[1].

[256934-83-5]

C21H22N2O4

366.41

CN1C=CC2=C1C=CC(C3=NCC(C4=CC(OC)=C(OC)C(OC)=C4)O3)=C2

Apoptosis; Microtubule/Tubulin

Room temperature