A-331440 [CAS 392338-13-5]

A-331440 is a potent and selective histamine H3 receptor antagonist that regulates neurotransmitter release by inhibiting presynaptic H3 receptors. In preclinical studies involving mice on a high-fat diet, A-331440 demonstrated dose-dependent effects on weight reduction and fat loss. At 5 mg/kg, it effectively decreased body weight comparable to dexfenfluramine, while at 15 mg/kg, it significantly reduced body fat and improved insulin tolerance, similar to mice on a low-fat diet. These findings suggest that A-331440 holds promise as an antiobesity agent by modulating histaminergic pathways involved in food intake and metabolic regulation[1].

[392338-13-5]

C22H27N3O

349.47

CN(C)[C@H](CC1)CN1CCCOC2=CC=C(C3=CC=C(C=C3)C#N)C=C2

Histamine Receptor

Room temperature

H319

P264-P280-P305+P351+P338