A-424274 [CAS 1335145-56-6]

A-424274 is a positive allosteric modulator of the α4β2 neuronal nicotinic acetylcholine receptor with activity to enhance the efficacy of analgesics. A-424274 selectively enhances the potency of a range of nicotinic acetylcholine receptor agonists at the α4β2 receptor and, in preclinical models, co-administration with an α4β2 PAM significantly enhances the analgesic efficacy of ABT-594 at clinically well-tolerated doses in humans.

[1335145-56-6]

C14H15N3

225.29

[H][C@]12CN(C3=CC4=CC=CC=C4N=C3)C[C@@]1([H])NC2

NAChR

Room temperature