A-953227 [CAS 1037826-77-9]

A-953227 is a highly potent and selective inhibitor with the activity of inhibiting calcium-dependent esterase (calpain) . A-953227 has enhanced selectivity for related cysteine proteases (cathepsins) and has shown good efficacy in cell experiments. A-953227 has shown broad efficacy in preclinical models for Alzheimer's disease, suggesting that it has potential benefits in inhibiting Alzheimer's disease[1].

[1037826-77-9]

C25H20FN5O3

457.46

O=C(C1=C(N=CC=C1)N2N=C(C=C2)C3=CC=C(C=C3)F)NC(CC4=CC=CC=C4)C(C(N)=O)=O

Ser/Thr Protease

Room temperature

H315-H319-H320

P264-P280-P302+P352-P305+P351+P338-P362