A-9758 [CAS 2055271-22-0]

A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation[1].

[2055271-22-0]

C25H23Cl2F3N2O3

527.36

O=C(C1CCN(C(C2=CC=C(Cl)C(CC(N3C)=CC4=C3C=C(C(F)(F)F)C=C4C)=C2Cl)=O)CC1)O

Interleukin Related; ROR

IL-17; IL-23; RORγ

10 mM in DMSO

Room temperature