Aβ-IN-4 [CAS 2477606-97-4]

Aβ-IN-4 (compound 12) is a potent amyloid β (Aβ) inhibitor. Aβ-IN-4 inhibits Aβ42 aggregation. However, Aβ-IN-4 can not alleviate the neurotoxicity of Aβ42 in SH-SY5Y cells. Aβ-IN-4 can not change the aggregation state of Aβ42 into a nontoxic one[1].

[2477606-97-4]

C33H43N5O7

621.72

O=C(N[C@@H](CC1=CC=C(OC/C=C/C[C@@H](C(N2)=O)NC([C@@H](N)CC(C)C)=O)C=C1)C(N[C@@H](C)C(O)=O)=O)[C@@H]2CC3=CC=CC=C3

Amyloid-β

10 mM in DMSO

Room temperature